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The patients will then be randomised into the TIPS and conventional therapy groups by means of a central randomisation system (http://openrct.fmmu.edu.cn).
Patients will then be randomised to physiotherapists.
Participants will then be randomised into the active intervention or waiting list control group.
Once patients have consented for the study, they will then be randomised in the operating theatre.
They will then be randomised and consented when they re-attend the clinic.
Participants who provide written informed consent will then be randomised, by cohort, according to Figure 1.
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Participants who are eligible to participate in the study will receive a baseline assessment, and then be randomised to either the FAST (intervention group) or control group (performing daily activity and receiving usual care) using a concealed matched-pairs randomisation method.
Patients presenting to heart attack centres with evidence of large infarcts (anterior territory) will have their bone marrow taken and then be randomised to receive either the mononuclear fraction from this sample or saline alone.
After consenting, patients will have baseline assessments, then usual care (fatigue self-management booklet, discussed for 5 6 min), then be randomised into control (no action) or intervention arms.
When all baseline questionnaires are collected, the family will then be centrally randomised by the be independently trial statistician, centrally randomised in a 1 : 1 ratio, into the intervention (I) or usual (U) care arms.
The patients will then be block randomised in equal proportions to the three treatment groups using randomly varying blocks of size three and six.
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