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In this context, quantiles equalization or other normalization tools will not substantially modify the change to detect patterns of different expression levels.
Unless you are wealthy and have a physical disability, which is a highly unusual combination, there's a limited chance of ever having designer garments that will fit you, unless you're willing to substantially modify a garment off the rack.
"It is likely that our policy will be substantially modified," Adams said.
In light of this, and given that diversity estimates for diatoms number into the hundreds of thousands of species, we expect that diatom plastid genomes hold many more surprises, that the full pan-genome is still unknown for diatom plastids, and that the inferences made here will be substantially modified in the coming years.
Technology will substantially change the lives of individuals.
Both techniques will substantially alter blood volume.
As explained above, we will be glad to substantially modify the manuscript text as well as perform possible additional experiments if these are considered to be important for providing additional support for the conclusions presented.
Although these changes will reduce uncertainty of individual dose estimates, they are not expected to substantially modify risk estimates.
Knowledge of result did not substantially modify these effects.
A state court interpretation of § 2600(4) would not avoid of substantially modify the constitutional question presented here.
It can substantially modify how the diffusion proceeds and its outcome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com