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The phrase "will substantially affect" is correct and usable in written English.
It can be used when discussing the impact or influence of one thing on another, particularly in formal or academic contexts. Example: "The new policy will substantially affect the way we conduct our business operations moving forward."
Exact(7)
He said there was a $15-20M15-20Mithen the regular budget, which will substantially affect the work of the Agency.
Both the emission yield (90.6 and 94.1% for 111In, 89.0% for 99mTc and 6.17 and 10.4% for 177Lu [39]) and the available energy window settings, as well as the source-detector distance (SDD), will substantially affect the measured sensitivities.
However, rising interest rates will substantially affect the ability for corporate issuers of sub-investment grade bonds to service their debt compared to those in higher credit rating brackets.
► Recent "changes to the Visa Waiver Program (VWP)... will substantially affect global scientific collaborations and exchanges," wrote Navid Madani of Harvard Medical School, in a letter in this week's issue of Science.
Temperature will substantially affect the diffusion rates of VOMs.
The clear communication of clinical sequencing results to families will substantially affect the value of those activities.
Similar(53)
Mr. Boey, though, believes the controls on junket operators in Singapore will not substantially affect the size of the V.I.P. market in the long term.
We assume that a lipophilic pollutant dissolved in such a triolein droplet will not substantially affect the development of a zebrafish embryo during this time.
"Whether... you decide to stay where you are or go somewhere else,... the only judgment that will really substantially affect your career prospects is research productivity".
The Unconventional Wisdom The softening world economy will not substantially affect the fortunes of the worlds ultra-rich, at least not yet.
The dirty secret is that higher wages, even at those 11% of restaurants owned by the corporation, will not substantially affect corporate's revenue.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com