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Obviously, most of these conformations (and in fact most seen using chromosome conformation capture (3C)) concern a population of cells and will not be refined until single-cell 3C is developed and implemented.
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But the oil may not be refined immediately.
If the script is scientifically accurate (unlikely), the villain will not be an oil refiner or a scheming executive from Detroit.
Such a procedure can be refined by an iteration procedure, but this will not be done in this case as there are rather few 'missing data'.
We envisage that this will not be a one-off process, but will continue through multiple cycles as additional questions are identified and refined.
If the estimation of occupancy is not right, the model will be refined against data resulting from the mixture of different conformations, which will affect the large-scale conformation, especially if the sample contains both cytoplasmically closed and open states.
Those nominations will then be refined by TechCrunch editors.
It will undoubtedly be refined by others in the future.
"I imagine it will be refined in some way in terms of the criteria, but at the minute I see no reason not to do it". Other cinemas are waiting for that refining to take place.
"Over the months the operation will be refined," Vieira said.
More are planned, and existing ones will be refined.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com