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This will necessitate rigorous validation in clinically annotated specimens with long-term follow up.
Subgroup analysis produced results using relatively small sample sizes; therefore, these findings necessitate validation on larger patient cohorts.
Model validation will necessitate multiple independent data sets and application of sophisticated statistical approaches.
State-space mapping of cellular responses to death-inducing stimuli will necessitate predictive, well-validated models.
The challenge is not simply a matter of cost relating to the equipment purchase, but also the fact that the installation of new equipment will necessitate a lengthy programme of qualification and validation work.
Such high dimensional imaging feature sets will necessitate machine learning algorithms of training/(cross -validation patient groups for feature selecross -validationarameter fitting, which may lead to robust risk stratification and outcome patiention of individual patients.
This will necessitate standardization of fMRI protocols (tasks and analyses), and their validation in different clinical populations [Allen and Fong, 2008; Binder et al., 2008; Rutten et al., 2002].
This will necessitate hard choices.
Those cuts will necessitate a charge of $160 million.
This will necessitate new design solutions based on new knowledge.
"But customer demand will necessitate some sort of way to make this work.
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