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In addition, adenine nucleotides are lost from the mitochondrial matrix, which will further sensitize the mitochondria to mPTP opening (Griffiths and Halestrap, 1995).
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Excess FA accumulation may further sensitize the liver for injury and inflammation.
Moreover, the taxanes may further sensitize cancer cells to a DNA damaging agents, such as doxorubicine.
Inflammatory cytokines from visceral adipose tissue or enteric sources further sensitize the liver to oxidative stress and cellular injury.
Such elevation of monocytes may further sensitize the lungs to the second hits such as infection and high-stretch ventilation.
Finally, we asked whether reduction in the expression of pyoverdine production enzymes such as PvdQ could further sensitize P. aeruginosa.
For each animal and testing day, this test was performed once, since repeated testing might further sensitize the nociceptive apparatus.
Alcohol also alters stress responses, causing elevation of peripheral cytokines, which further sensitize neuroimmune responses to ethanol.
However, depletion of UHRF1 in cells in which FANCD2 was already depleted did not further sensitize the cells.
Interestingly, siRNA knockdown of MDR1 further sensitized the cytotoxic activity of paclitaxel when co-administrated with H6.
While passing through the target, each ion creates a cylindrical damage zone along its trajectory which is further sensitized by UV light exposure for 2 h.
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