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Given the increased levels of TLR2 expression in co-infected animals we hypothesized that this receptor may be a determinant of the increased severity of inflammation in this group and that TLR2−/− animals will exhibit attenuated levels of lesion severity and inflammation, in response to co-infection.
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This suggests that mono-functional group I BPLs exhibit attenuated affinities dedicated to perform only enzymatic function.
Accordingly, CyaB is an important regulator of Vfr-dependent functions; ΔcyaB and Δvfr mutants exhibit attenuated virulence in a mouse model of acute pneumonia infection [19].
Meninges covering the ventral delineation of the hypothalamus and pons exhibit attenuated expression (2C).
29 In addition, carriers of this mutation also exhibit attenuated heart rate responses to stress.
A greater number of photosensitive cells might argue for enhanced light responses, however, these mice exhibit attenuated phase shifting behaviors.
First, individuals with a parental history of hypertension exhibited attenuated pain sensitivity.
However, both male and female TS rats exhibited attenuated AMPH sensitization compared to sex-matched controls.
MHC class II knockout mice exhibited attenuated allodynia following spinal nerve transection as compared to wild-type control mice.
Therefore, K/R cells exhibited attenuated differentiation, as indicated by lipid accumulation, mRNA and protein expression.
As shown in Figure 3B, mice treated with the NAF exhibited attenuated Aβ-induced impairment in a dose-dependent manner.
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