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At the beginning of each intervention session, resting heart rate (HR) will be recorded after a period of quiet sitting.
Electromyographic signals will be recorded after cleaning the skin with 70% alcohol to reduce skin impedance and to allow proper placement of surface electrodes.
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Goal attainment scores will be recorded at baseline, after three months of blinded treatment and after nine months of ITB treatment.
The primary clinical outcome (pain intensity) and the secondary ones (sensory and affective aspects of pain, physical functioning and global perceived effect) will be recorded before treatment, after four weeks, in Month 3 and in Month 6 after randomization.
The pilot of Frankie Boyle's Rehabilitation Programme will be recorded in October, after which an immediate decision will be made on whether to proceed to a full commission.
The primary outcome measure will be recorded 6 weeks after the expected due date.
The PPT at the low-back algometry points will be recorded 30 seconds after immersion.
The primary outcome measure will be recorded 10 weeks after the expected term date.
35 Oxygen saturation, heart rate and symptoms of leg effort and dyspnoea will be recorded before and after the test.
Each child will go through a vigorous six minutes free running exercise in the school playground and their heart rate will be recorded before and after exercise as a measurement of the level of exercise stress achieved.
Potential adverse effects of ephedrine will be monitored as follows: vital signs will be measured 30, 60 and 120 min after administration of study medication on the first day of periods 1 and 2. In addition, an ECG will be recorded 60 min after medication is administered on these days, and also during the hospital visit in weeks 1, 2 and 6.
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