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Within each site, dyads will be randomized to ensure treatment balance after every 20 randomizations.
Participants will be randomized to NAC or placebo treatment by a computer-based random eight block number generator.
Site pairs will be randomized to intervention versus control.
Participants will be randomized to BT or SC.
Dyads will be randomized to either the FACE-TC intervention or Treatment as Usual (TAU) control.
Consenting subjects will be randomized to therapy directed by FDG PET or standard care.
The plate layout of DNA samples for genotyping will be randomized to avoid systematic bias introduced from laboratory method conditions.
Only those able to maintain euthymia for 4 successive weeks (app. 120) will be randomized to either SBAA+ or SBAA.
Families will be randomized to one of two conditions: (a) behavioral family based intervention or (b) a waitlist control.
Participants with at least one CVD risk factor will be randomized to either a lifestyle intervention or a control group.
One hundred forty-one participants will be randomized to 1 of 2 exercise grouparticipantsexercise control.
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