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It will be possible to include 250 THA patients and 250 shoulder patients in a one-year inclusion period.
We, however, note that it will be possible to include such reliability information, if available, by appropriately modifying the feature scoring system.
This setting will enable a bigger sample size and with 7 months follow-up it will be possible to include long term monitoring.
In future, with the availability of more force field libraries, it will be possible to include other non-natural modifications in PEPstrMOD.
We are uncertain whether it will be possible to include psychological interventions as the information available to us suggests that these trials are very different from trials of pharmacological agents.
In the context of ancillary protocols dealing with different themes of scientific interest, it will be possible to include specific questionnaires for the overall population or subsamples chosen according to particular phenotypes (age, sex, region, health status, etc).. Participants will be invited to fill in these questionnaires once they are connected to the study's web site.
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Even so it will not be possible to include every letter.
Nevertheless, given the extent of difference, along wide-ranging lines (i.e. ethnicity, country of origin, legal status etc)., it will not be possible to include a representative sample of all groups.
However, limited funding for this project means that it will not be possible to include more costly measures, such as accelerometers, that would likely provide more detailed data regarding physical activity.
In this way, it will be possible to identify and include most of the patients from a single catchment area who meet the study criteria.
We expect that, by testing the in vivo activity of cdODN199, it will be possible to introduce refinements, including the addition or removal of certain PRE elements.
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