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Most of the mutations will be deleterious.
The finding of an increase in average growth rate resulting from secondary insertion mutations in the dps-deleted strain was unexpected because it is usually assumed that most mutations, especially large mutations such as transposon insertions, will be deleterious.
The genome state influences the rate and distribution of selection coefficients for mutations in individuals: the better the population is adapted, the more sites are fixed at beneficial alleles and the more novel mutations will be deleterious.
But the mutations can generate an incredible number of effects on the phenotype, and most of them will be deleterious under any circumstances, if not lethal.
He also worries that the U.S.'s high level of unfunded future liabilities will be deleterious to its creditworthiness, making it more difficult to find buyers for its mounting debt.
B-SIFT produces scores in a way consistent with the expectation that many more mutations will be deleterious than activating.
Similar(42)
This ill will is deleterious both to these students — who make up the overwhelming majority of the student population — and the reputation of the public-school system of our great and historic city.
This is because if TEs tend to affect gene expression when they insert in a particular region then they will generally be deleterious and therefore removed by natural selection.
Most amino acid changes will likely be deleterious and quickly eliminated by purifying selection [ 2, 3].
Hence, we understand that the use of the Brazilian Portuguese versions of this instrument with the underlying factor structure generated during the original cross-cultural project will not be deleterious in any way.
Hence, defective mitochondrial function will almost inevitably be deleterious to cell and tissue functions threatening the well-being of the entire organism.
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