Exact(3)
Conceptual change, in this perspective, involves altering the structured priorities of knowledge elements - i.e., altering the likelihood that particular pieces of knowledge will be activated upon recognition of specific contextual cues.
At present we do not have the evidence that at the same time all lymphoid organs will be activated upon intravenous infection or that the parasympathetic output to the lymphoid organs is regionally organized just as the output to other organs of the body[32].
For example, the NF- κB signaling pathway in epithelial cells and some intestine-specific immune cells will be activated upon the interactions between their toll-like receptors and luminal bacteria, which stimulate the epithelial proliferation as well as lead to immune tolerance of intestine to foreign antigens.
Similar(5)
Upon transcriptional activation, several target genes will be activated including Axin2, c-fos, c-myc and many others, which are important for proliferation and/or cell-fate decisions.
Upon radiation exposure, these checkpoints will be activated which provides time for DNA repair and thereby promote genomic stability [ 3].
GRP78 is a physiological substrate for calpain II, which will be activated at the ER membrane by interacting with GRP78 upon drug stimulation.
Upon PLN's phosphorylation, Ca2+ pump will be activated leading to muscle relaxation.
Since GraS and GraR constitute a TCS, it is supposed that upon intercepting a signal the GraS kinase will be activated through a trans-autophosphorylation process, whereby a conserved histidine residue of GraS will undergo phosphorylation.
Related(2)
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