Sentence examples for wild-type screens from inspiring English sources

Phenotypic screens against ABC16-Monster, which lacks 16 drug efflux pumps that might otherwise reduce intracellular inhibitor concentrations, may identify potential drug leads that would be missed in wild-type screens.

We benchmarked our computationally derived localization assignments for one of our wild-type screens, WT1 (Chong et al. 2015), to visually assigned localization annotations from YGFP (Huh et al. 2003) and found 94% agreement among the set of 1097 proteins assigned to a single location by both methods (Chong et al. 2015).

CYCLoPs currently contains a total of 330,248 images from three wild-type screens, three screens with a strain deleted for the gene encoding the conserved lysine deacetylase Rpd3, and time courses of two chemical treatments (hydroxyurea and rapamycin; Table 1).

We first segmented the cells from micrographs obtained from our wild-type screen.

The Ig measurements from our wild-type screen were highly correlated with protein abundance measurements from other techniques, namely flow cytometry, western blot analysis, and mass spectrometry (Chong et al. 2015).

Two strains of zebrafish (AB and Singapore-based wild-type) were screened using the custom-designed aCGH array.

However, in the present series of 31 adult wild-type GISTs screened for SDHB protein, 16 exhibited high relative IGF1R expression, but only three of these were SDHB deficient.

Homologous integration of this cassette into wild-type cells and screening by PCR for genomic (G), Vector (V) and knockout (KO) PCR products for the 5′ and 3′ targeting region identified independent pkd2-mutants.

Thus wild-type POMGnT1 was screened against a library of 21 mannopeptides produced by SPPS, which was optimized for the introduction of Fmoc (fluoren-9-ylmethoxycarbonyl -protected fluoren-9-ylmethoxycarbonyl -protected building blocks.

To investigate if senescence triggered by Recql4 mutation has a role in sparse hair, tail sections from Recql4 mutant mice as well as wild-type mice were screened for SA- β-gal staining.

Although in this study we considered only the screening of reaction knockouts from a wild-type metabolic network, FastPros screening would be applicable, for example, after the addition of heterologous reaction pathways to produce desired non-native targets (Chatsurachai et al., 2012; Cho et al., 2010; Pharkya et al., 2004).