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The proteins of this family that contain only the BH3 domain are pro-apoptotic and function as initial sensors of apoptotic signals resulting from various cellular processes, whereas the pro-survival Bcl-2 family members, such as Bcl-2 or Bcl-xL, wield their effect by binding and sequestering their pro-apoptotic counterparts [ 11].
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These molecules either rely on SHP-1 (CD5 or CD72) or SHIP (CD22 and CD32) to wield their repressive effects.
Others wield their pens in tribute.
Their mournful survivors must wield their shovels on their own.
The pirates may be past their heyday, but they will continue to wield their cutlasses.
EDITORIAL cartoonists, who wield their pens like darts, probably never lack for targets.
This time, they were determined to wield their influence as a bloc.
Finally, we insisted that they actively wield their power.
Other birds use their wings as weapons, too, but none wield their hand bones like clubs.
Some people wield their money like a weapon..
'They cut their teeth in the public system; they wield their power and have no compassion at all.
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