Exact(7)
Patients usually present with multiorgan failure, and the possibility of widespread vasculitis should be considered.
Widespread vasculitis, which is defined as involvement of the skin and at least two other organs, may develop (Table 1; Figure 1) [9–15, 15, 20 23].
Finally, B-NHL and widespread vasculitis may complicate a minority of cases; they represent the most harmful manifestations of the disease [ 1, 2, 4].
The widespread vasculitis or perivasuculitis in scrub typhus may involve the lung, cardiovascular system, brain, kidney, gastrointestinal tract, liver, and lymph nodes [ 4, 17- 21].
Widespread vasculitis, which is defined as involvement of the skin and at least two other organs, may develop (Table 1; Figure 1) [ 9- 15, 15, 20- 23].
All developed respiratory failure requiring invasive mechanical ventilation, haematological failure with haemolytic anaemia and acute renal failure suggestive of serious widespread vasculitis.
Similar(53)
Fluorescein angiography demonstrated widespread retinal vasculitis which is a rare manifestation of rifabutin-associated uveitis.
Finally, the diagnosis was widespread cryoglobulinemic vasculitis with skin, lung, and kidney involvement secondary to monoclonal gammopathy of undetermined significance associated with Sjögren's syndrome.
The histopathologic finding of widespread necrotizing vasculitis supports the current understanding of the pathogenesis of HeV infection, during which virus binds to the endothelial ephrin-B2 transmembrane protein receptor (7 ) and localizes in vessel walls, leading to endothelial cell damage.
Figure 1 Widespread fulminant cryoglobulinemic vasculitis is defined as involvement of the skin and at least two other organs, such as illustrated by the following case.
These changes are consistent with the neuropathogenesis of Henipavirus-related encephalitis (widespread viral endothelial infection with resultant vasculitis, syncytial giant cell formation, and ischemic necrosis) (12 ).
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