Inhibitor binding induces widespread structural changes, including rotation of the head and closure of the lateral cleft.
Findings from neuroimaging studies in patients with schizophrenia suggest widespread structural changes although the mechanisms through which these changes occur are currently unknown.
Widespread structural changes suggesting abnormal connectivity in schizophrenia have been imaged.
Given widespread structural changes in GM, it seems plausible that white matter (WM) is also affected, and a few studies have suggested this to be the case: Analyzing T1w images with tensor-based morphometry, Raji et al. [16] found atrophy in the corona radiata in overweight subjects.
Chronic pain disrupts the so-called "default mode network" of the brain [59] and may lead to widespread structural changes of the in animal as well as human brain [60], [61] Reduced neuronal metabolism in several brain regions has been demonstrated by magnetic resonance spectroscopy [62].
Consistent with this arrangement, the SWR1-ΔN-Mod subcomplex exhibited more widespread structural changes than SWR1-ΔC-Mod, with changes in the Rvb1/Rvb2 ring detected in the 2D difference maps.
Removal of the nucleophile by mutation to Ala disrupts the population of a reactive state and causes widespread structural changes from a conformation that promotes autoproteolysis to one associated with substrate catalysis.
Recent studies using quantitative structural magnetic resonance imaging have shown widespread morphological changes in RE [ 7– 11].
With cuts forcing dramatic structural change and widespread redundancies, one of the most difficult issues public sector managers are facing is how to mitigate the loss of staff with years of expertise and accrued knowledge.
In the past decade, advances in genome analysis methods have highlighted the widespread presence of structural changes in normal and disease-affected human genomes [ 32– 32].
