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Drugs like Prozac and Paxil specifically target the serotonin systems, thereby avoiding the widespread side effects of the older generations of antidepressants.
However, single miRNAs have numerous targets, enabling them to regulate a wide range of genes, with the potential for widespread side effects.
Current available therapeutics option or their application are severely limited owing to the widespread side effects.
In a large number of clinical cases, cancer-associated pain, particularly the neuropathic component thereof, is resistant to conventional therapeutics or their application is severely limited owing to the widespread side effects (Mantyh, 2006; Portenoy, 1999).
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A widespread side effect of the dominant youth culture is older people insisting on loving it and then turning their scorn on their skeptical peers.
This implies that a large proportion of children in 2014 took treatment on an empty stomach with the risk of widespread side-effects.
Potential disadvantages of more widespread antimicrobial prophylaxis (side effects and cost of antibiotics, development of antimicrobial resistance) might be mitigated by the identification of which patients are most likely to benefit from this approach.
There, weak health infrastructure and widespread rumours about vaccine side effects contributed to the spread of the crippling virus.
By Associated Press Writer MARIA DANILOVA Kyiv, 25 March 2009 (AP) — A widespread scare about vaccine side effects in Ukraine has led to a sharp drop in immunizations that could result in disease outbreaks spreading beyond the former Soviet republic, international and local health officials say.
"We demonstrate that loss of hippocampal volume in late adulthood is not inevitable and can be reversed with moderate-intensity exercise," the team wrote, suggesting that a few laps around the track might be a particularly cost-effective way to treat a widespread health problem -- without the side effects of medication.
Side effects are widespread.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com