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To those who know the Ireland coach his understated manner is legendary, and now that he is in charge of a team of grand slam champions that perpetual half-smile and the soft, breathy delivery rooted just behind the front teeth is getting a widespread projection it was perhaps not designed for.
One aspect of the argument that CA3 pyramidal cells have a widespread projection is based on a part of its axonal arbor that has received relatively little attention, the collaterals that project in the opposite direction to the trisynaptic circuit, "back" to the dentate gyrus.
This nucleus consists of 90% cholinergic neurons and its' widespread projection axons provide the main cholinergic innervation to the entire cortical mantle ('corticopetal' innervation) (Mesulam et al., 1983; Mufson et al., 2003; Gratwicke et al., 2013) (Figs 1 and 3).
They also demonstrated a widespread projection pattern for these neurons with the highest density of terminals observed in the paraventricular nucleus (PVN) and the dorsomedial hypothalamus (DMH) [ 14,15,18].
The apparent lack of research on the link between indoor air pollution and birth weight is totally at variance with the widespread projection of indoor air pollution as the most important environmental exposure for pregnant women especially in developing countries due to the effects of second-hand smoke.
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Ford said it planned to increase production by 9 percent in the second quarter, despite widespread projections that gasoline prices could hit $4 this summer.
Hypocretin-containing neurons have widespread projections throughout the CNS with particularly dense excitatory projections to monoaminergic and serotonergic brainstem centers [80].
Hypothalamic excitatory hypocretin (orexin) neurons have been discovered in 1998 and found to have widespread projections to basal forebrain, monoaminergic and cholinergic brainstem, and spinal cord regions.
The hcrt/orx neurons exert their influence during waking when they discharge selectively [5], [6], and through widespread projections [7] and excitatory actions upon multiple systems including all the activating and arousal systems in the brain [8].
Giving rise to widespread projections throughout the brain [5], they play a central role in promoting waking through the excitatory actions of their peptide upon multiple arousal systems [6] [10].
A core thalamic system of PV+ neurons acts as a relay, and a CB+ matrix appears to be engaged in intrathalamic corticocortical communication through widespread projections to superficial cortical layers [19].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com