Sentence examples for widespread pathology from inspiring English sources

The size of the CAG repeat expansion in both the R6/2 and HdhQ150 models is of a size that would cause childhood disease in humans and would be expected to result in a more widespread pathology than CAG repeat expansions in the adult onset range.

In light of this widespread pathology, we believe that our data are not inconsistent with demonstrations of impairment in timing procedures in subjects with Parkinson's and Huntington's Diseases as the deficits in the latter conditions may reflect the effects of dysfunction of brain circuits other than the basal ganglia (cf., [37], [21]).

Hepatotoxicity is the most widespread pathology worldwide, representing up to 83% of all cases.

Finally, widespread pathology in peripheral tissues including skeletal muscle, heart, bone and testis, are beginning to be recognized.

Production of antigenic peptides could potentially enable even a small fraction of DUX4+ nuclei to induce widespread pathology within a muscle fiber.

The frequent occurrence of multifocal lesions or even fulminant widespread pathology in some of these models perhaps emphasizes this point (14, 92).

We had attributed these widespread pathologies in the R6/2 mouse brain to the expression of a small N-terminal fragment of Htt and therefore were surprised to find that it was also a feature of the HdhQ150/Q150 mice.

To this end, we relied on published data [ 3, 4] regarding the four most significant and widespread pathologies concurrent with PE: DM, Ob, GD and pyelonephritis.

14 An important question thus concerns the extent to which the features of the Mid Staffordshire case might be symptoms of more widespread pathologies, given that other organisations in the NHS are exposed to the same institutional and regulatory environment.

Our data that soluble non-amyloidogenic αS can induce widespread αS pathology raises questions regarding the "prion-like" spread of pathology that has been reported, but it is premature to conclude that our studies definitively refute that mechanism.

But they wrote that "widespread CTE pathology... is unusual in such a young football player".