In early pregnancy failure, the development of the placento-decidual interface is severely impaired leading to early and widespread onset of maternal blood flowing continuously inside the placenta, together with major oxidative stress induced tissue degeneration [8], [9], [13].
This underscored the gap in our ability to detect and characterize emerging strains before the widespread onset of disease in the population.
Ernest Drucker, my colleague and a professor of epidemiology as well as family and community medicine, classifies incarceration as an epidemic because it is a situation with widespread and rapid onset over 35 years, it affects a disproportionately large number of people within a population, and its spread and adverse effects are felt even by those who are not incarcerated.
Notably, preictal changes were common, and had a fairly characteristic time signature and tended to be more widespread than at onset.
Moreover, patients with RA are known to develop early-onset, widespread calcification in various vascular beds [ 13– 15].
A flattened diurnal cortisol profile predicted new-onset widespread pain among individuals with high somatization and health-seeking behaviour in a British study [ 10], and another population-based study also showed that chronic multi-site MS pain was associated with lower cortisol levels and blunted diurnal slope [ 8].
A widespread belief about the onset of puberty in girls is coming under vigorous attack, led by a group of medical specialists who say that it is based on flawed science and that it can have dire medical consequences.
In past cases, a trigger — a farmer spraying pesticides next door, a propane leak, a new girl having an epileptic seizure — has caused widespread panic and the onset of the familiar symptoms.
As he explained in a recent e-mail message, a "likely cause" of the widespread delay in the onset of maturity today was "more prolonged higher education for ever more people, leading to an increase in the 'unfinished' personalities that are adaptive to learning".
The prevailing winds transported the volcanic ash over large areas of the Northern hemisphere and, soon after the eruption onset, caused widespread airport closure in Northern and Central Europe.
Faced with the magnitude of this task, some scientists declare that there is a long road still to be travelled before we see the onset of widespread use of solar fuels.
