Sentence examples for widespread mutations from inspiring English sources

The recent findings of highly recurrent activating mutations in the promoter for the telomerase reverse transcriptase (TERT) gene in diverse human cancers, together with the widespread mutations in p53 in cancer, provide support for the idea that circumvention of a telomere-p53 checkpoint is essential for malignant progression in human cancer.

A genetic study of malaria parasites across Myanmar, published online today in The Lancet Infectious Diseases, has found widespread mutations in a gene that plays a key role in resistance to artemisinin, the best drug available to cure the disease.

MSI-high tumors have been shown to exhibit widespread mutations in nucleotide repeat sequences such as those in TGFBR2 and BAX [49], [50].

In conclusion, rare RBC mutations such as PK deficiency and GR deficiency resist malaria infection and may provide protection by the same paradigm applicable to widespread mutations such as those affecting hemoglobin, G6PD, or membrane proteins.

Sequence comparison revealed four widespread mutations, I161V, G265A, F330Y and G368A.

A recent screening allowed the identification of four widespread mutations, I161V, G265A, F330Y and G368A.

"For such a very strong change, a lot of people would have had to die simply due to the fact that they had the wrong version of a gene". The widespread mutation in Tibetans is near a gene called EPAS1, a so-called "super athlete gene" identified several years ago and named because some variants of the gene are associated with improved athletic performance, Nielsen said.

And other studies have shown that a single widespread mutation in mitochondrial DNA can cause cells to atrophy.

More generally, developmental instability is associated with worse health outcomes, illness, and fetal stresses [27], which could be due to deleterious effects of widespread mutation and explain links of intelligence with mortality.

They have been applied to correct a number of mutations using minigenes or endogenous transcripts in genetic disease context like hemophilia A [10], spinal muscular atrophy [11], X-linked immunodeficiency [12] and cystic fibrosis where the widespread mutation CFTRΔF508 was replaced efficiently in vivo by the normal sequence via a trans-splicing reaction [13].

This widespread mutation appears to have the highest worldwide frequency in Lebanon.