We have moved the former Figure 6 figure supplement 2 to Figure 6 figure supplement 3. We thank the reviewer for the suggestion, and agree that some comparison between the variance explained by local and widespread models is informative.
I think, however, that he understates just how widespread the model is now.
For single fault injection, one can already see that the probability of transitions among these attractors in the SIN model is more widespread than in SIF model on the same network.
However, the Dzombak and Morel [4] model has been carefully calibrated with a very large dataset (including many metals besides Cu), and this model is already in widespread use.
Limitations and future directions The hyperalgesia that develops in this model is generally considered widespread and includes bilateral hindlimb muscles, paw and viscera [ 6, 25]; however, it is unclear if there are changes in other areas of the body, such as the forelimbs.
Predicting the geographic distribution of widespread species through modeling is problematic for several reasons including high rates of omission errors.
Last ,because interoperability and collaboration are paramount to reducing costs, we wished to investigate if any file formats for the exchange of Virtual Patients have been suggested or proposed by any research groups, or if any existing standards, such as SCORM (Sharable Content Object Reference Model) are in widespread use.
The use of surrogate models to approximate computationally expensive simulation models, e.g., large comprehensive finite element models, is widespread.
The use of mathematical and simulation models is widespread in ecology, and individual-based models (IBMs) have proved valuable for exploring individually-explicit interactions and behaviour.
Widespread application of these models is encouraged, however for this to be realised necessary parameter values, such as pollen productivity estimates require further investigation.
