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However, widespread linkage disequilibrium generated and maintained by self-fertilization is predicted to reduce the efficacy of purging when mutations are present at multiple loci.
Furthermore, we have demonstrated widespread linkage of many GATA456 duplicates, suggesting a mechanism of gene duplication via tandem duplication events and providing further evidence in support of duplicate-orthology.
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Despite its widespread availability in linkage software packages, its use by numerous linkage groups, and its recognition as a key step in the record linkage process, the record linkage literature has not extensively explored data cleaning in its own right.
However, the difficulty in obtaining a sufficient number of evenly distributed molecular markers severely restricts the widespread applicability of linkage analysis using cross combination within temperate japonica cultivars.
Capitalism entered world history at roughly the same time that individual freedom caught on as a widespread goal, and this linkage was not accidental.
Such failure or delay in outpatient care linkage is widespread and has been well documented.
The availability of large medical databases and unique person identifier (ID) numbers has made widespread use of record linkage possible.
However, staffing, organisational structure and financing factors serve to entrench the biomedical view of health despite widespread awareness of the linkages between health and its social, environmental and political determinants.
Previous linkage studies showed widespread recombination in the spinach sex chromosomes except in the vicinity of the male-determining factor (Y) (Khattak et al. 2006; Onodera et al. 2011; Yamamoto et al. 2014), consistent with little or no morphological differentiation of the sex chromosomal pair in Group 1.
All but seven of the mapped SNPs map to 618 genome scaffolds; 260 scaffolds contain two or more mapped SNPs, but for 100 of these scaffolds (38.5%), the contained SNPs map to different linkage groups, suggesting widespread errors in scaffold assemblies.
This development set the stage for the widespread use of genome scans followed by linkage analysis or homozygosity/autozygosity mapping, followed by comparative positional candidate gene analysis.
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