(N – Q ) IHC for the PanIN marker, CLDN18, highlighting intermittent PanIN formation in Kras G12D mice and widespread lesion development in Ptf1a conditional knock-out (cKO); Kras G12D.
In rheumatoid arthritis (RA), bone edema has special significance as it has been shown to be a common and widespread lesion that is often apparent at the hands and wrists but has also been described elsewhere, including the feet.
Besides, the patient presented widespread lesions of molluscum contagiosum on the anterior face of the thorax and the limbs.
For widespread lesions, however, current endoscopic treatment modalities (eg, endoscopic resection, argon plasma coagulation, photodynamic therapy) are associated with considerable drawbacks, of which esophageal stricturing is the most significant.
Even though surgical excision is the most effective treatment, an excessive excision brings about motor dysfunction, massive bleeding, cosmetic problems, and nerve damage in patients with widespread lesions because of the complicated anatomy of the head and neck region [3, 17].
Eleven percent of asymptomatic patients had widespread lesions, compared with 40.0% of symptomatic patients.
TSC mostly affects children, who develop widespread lesions, known as hamartomas, in different organs, including the central nervous system (CNS).
The widespread lesions in both eyes were not typical of any of the inflammatory choriocapillaritis or stromal choroiditis disorders.
The severity of clinical signs ranges from asymptomatic to moderate, although widespread lesions can be seen in immunocompromised rabbits [ 1- 3].
Widespread lesions in the CNS may involve gray matter and leptomeninges of the brain stem, medulla oblongata, nuclei, cerebellum and spinal cord (for review see [ 4, 5]).
Thus, forced PSA expression on Schwann cells may have important therapeutic implications for the treatment of myelin diseases with widespread lesions such as those encountered in multiple sclerosis.
