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Researchers suspect that all the ailments stem partly from the same underlying condition, widespread inflammation, a reaction by the immune system that can affect blood vessels, organs and tissues all over the body.
Sepsis is a condition in which the immune system overreacts to infection, releasing inflammatory mediators into the peripheral blood and triggering widespread inflammation.
Psoriatic erythroderma (erythrodermic psoriasis) involves widespread inflammation and exfoliation of the skin over most of the body surface.
The findings from a post mortem are usually a widespread inflammation of the pia mater and arachnoid layers of the meninges.
But among those with high pre-surgery levels of "bad" cholesterol and evidence of widespread inflammation, the changes were large enough that they could not be attributed to chance.
On the other hand, specific IgM against flora may be part of a protective mechanism mounted by the immune system to limit subsequent translocation and widespread inflammation.
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In wild type mice, OVA induction led to widespread peribronchiolar inflammation (Figure 2B, left panel).
Infected immunocompetent animals exhibited widespread perivascular inflammation, which subsided by 8 weeks.
Alveolar hypoxia produces widespread systemic inflammation [ 45] and it also promotes the development of a pulmonary artery chronic inflammatory microenvironment [ 46].
Global deletion of FOXO3 is not lethal but affects lymph proliferation, widespread organ inflammation [ 4], age-dependent infertility [ 3], and decline in the neural stem cell pool [ 5].
Direct rickettsial invasion of the nervous system has been described in patients with acute neurological complications, but subacute involvement of rickettsiosis is believed to be secondary to immune-mediated mechanisms caused by widespread endothelial inflammation and progression to a vasculitic process that may affect any organ 32, 33.
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