Depositions of TTR-derived amyloid are found widespread in heart, kidney, eye and other organs [1], [2] indicating the systemic and heterogeneous nature of these disorders.
Expression patterns vary extensively: Tropomodulin 3 (TMOD3) is ubiquitous; Tropomodulin 1 (TMOD1) is widespread in heart, muscle, brain, lens, erythrocytes, and arterioles; Tropomodulin 2 (TMOD2) is restricted to neuronal tissue; Tropomodulin 4 (TMOD4).
With Dr. William Frishman at Einstein, Dr. Sonnenblick was a pioneer in bringing beta blockers into widespread use for heart failure.
"Doctors Rethink Widespread Use of Heart Stents" (front page, Oct. 21) did not mention a key point that every physician knows: coronary artery disease is a systemic illness affecting the entire circulation, and target-specific remedies like stents place Band-Aids on a bigger problem.
Physiologist John Hall of the University of Mississippi Medical Center in Jackson calls the paper "an exciting new idea," but points to another reason to question whether the results will apply to people: Beta blockers, which are drugs that block BDNF, have been in widespread use for heart disease since the 1960s, yet there's "no evidence that they promote tumor growth," he says.
Although a larger clinical end-point study is required, we believe that this report has implications for the widespread practice of heart rate reduction in this context.
In WT hearts, widespread CENP-F expression is observed throughout the myocardium (Fig. 1E,F), whereas expression is absent in the myocardium of CENP-F −/− mice (Fig. 1G,H).
Heart rot, widespread disease of trees, root crops, and celery.
The roots of widespread ailments such as heart disease and diabetes, although more complex and possibly involving up to a dozen genes, would soon follow, it was expected.
Dr. Karlsberg and other cardiologists who support widespread use of CT heart scans argue that they can reduce the need for other tests — like conventional angiograms, which can find plaque but require a catheter to be threaded through the arteries.
