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The widespread expression pattern of TGF-βs in epithelial cells suggests that this family of peptides may play important roles in the maintenance of epithelial homeostasis.
This widespread expression pattern of histone genes may be due to the fact that histone proteins play a critical role in variety of chromosomal processes [ 1], suggesting many genes that are coregulated with histone genes.
Similar to the well documented widespread expression pattern of human [ 26, 27, 42], rat [ 28], mouse and guinea pig [ 5] grns in several tissues and cell lines of epithelial, mesenchymal, and hematopoietic origin, both grna and grnb were observed to be expressed ubiquitously in several adult zebrafish organs.
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Each PKA subunit gene has been individually disrupted in mice [8] [14] and despite the widespread expression patterns of R and C isoforms, only the disruption of RIα results in embryonic lethality [11].
The widespread expression patterns of Fras1 lead to the hypothesis that epithelial-derived Fras1 plays roles in the biology of not just the UB but also CDs and glomeruli.
Although these data do not rule out a role for the LCR in Dad1 gene expression, other elements in the Dad1 locus are clearly required to generate the full widespread expression pattern characteristic of this gene.
This widespread expression pattern makes the use of fibroblasts derived from skin biopsies a relevant model system for the investigation of the cellular impact of mutations in AP5Z1.
In this study, we identified a unique transgenic silkworm strain whose reporter gene showed strong and widespread expression pattern during the process of enhancer trap strain establishment.
positive expression, no expression, FISH analysis (F), not determined (nd) MSX2 showed the most widespread expression pattern as detected in 22/24 922%) of the analyzed cell lines and, therefore, may represent a promising candidate physiological NKL in T-cells.
We examined expression of UIF in chick embryos and found a widespread expression pattern during development.
This widespread expression pattern is purportedly due to MRP8 spliceoforms [175].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com