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The study demonstrates a widespread divergence from internationally accepted practice.
Comparative transcriptional profiling of adult interspecific hybrids and their parental species has uncovered widespread divergence of the mechanisms controlling gene regulation, revealing incompatibilities that are masked in comparisons between the pure species.
The duplication event recorded here differs in nature because its effects on genetic complement go beyond spatio-temporal fluctuations in copy number; the duplicons evolved through deletion of many genes, gain of a few others, and widespread divergence of retained paralogs, to create a novel and permanent addition to the T. brucei genome.
None of the remaining 19 could have been predicted by simple homology; due to their widespread divergence, and absence of motifs for most NHRs, few motifs can be predicted by homology among the C. elegans NHR class at our threshold for motif prediction (70% identity for NHRs).
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We show broad conservation of Dichaete and SoxN regulatory networks coupled with widespread binding divergence at a rate that is consistent with studies of other TFs in Drosophila.
In concert, these findings inform a general argument that hydrologic fragmentation and the novel ecosystems generated as a consequence drives widespread evolutionary divergence in a variety of wild fish populations.
As noted elsewhere, widespread genomic divergence is not surprising in view of low gene densities in the centromere-proximal regions and the multifarious nature of phenotypic differentiation between M and S (White et al. 2010; Weetman et al. 2012).
In addition, direct experimental tests of selection and finer-scale sequencing commonly identify widespread genomic divergence resulting from selection and speciation, often contrasting earlier works that identify only a few such regions (e.g. Michel et al. 2010; Hahn et al. 2012).
It is worth noting that sRNA libraries we used for comparative analysis for a given plant were all derived from the same genotype and generated by the same laboratory, and have been used to explore the widespread conservation and divergence of microRNAs in plants [ 33].
But no matter how long the list of joint projects, technical dialogues and substantive agreements, there is a nagging sense that until a major new initiative is found, charges of drift and divergence – the "widespread" impression that "relations are on a plateau, if not in the doldrums," as a former Indian ambassador to the United States observed on Thursday – will dog the relationship.
A series of detailed studies showed sharp genetic discontinuities between populations of western Mediterranean Veronica subgenus Pentasepalae, in spite of limited morphological divergence and widespread homoplasy [43] [46].
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