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Many splicing regulators have tissue-specific expression patterns, resulting in widespread differences in AS patterns across different tissues.
From the entire GO-slim set of 148 terms, 39 biological process terms, 20 molecular function terms, and 29 cellular component terms were found to significantly differ between annotated transcriptomes suggesting widespread differences.
It is important to note that different signatures may share common genes, yet show widespread differences at the same time.
At the level of isoform characterization, we discovered widespread differences in the use of tandem alternative polyadenylation (APA) sites by methylated and nonmethylated transcript isoforms of individual genes.
Our results show dramatic variation in IR among strains of mice and widespread differences between sexes that are dependent on genotype.
An international observational study led by Columbia University researchers has uncovered widespread differences in the treatment of patients with common chronic diseases, including type 2 diabetes, hypertension, and depression.
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A widespread difference in grey matter volume was found across many brain regions, whereas cortical thinning was mainly restricted to central areas.
The picture that emerges is one of forests far from equilibrium, with both growth and mortality rates having risen and with a persistent and geographically very widespread difference between the two that implies a carbon sink into mature forests across the whole region.
This finding is consistent with the findings of a multicentre study [ 19] which reported a widespread difference between countries in the prevalence of pacifier use ranging from 12.5% in Japan to 71% in the Ukraine.
Our results confirm the presence of widespread epigenetic differences induced by MD in chicken lines with different levels of genetic resistance.
Lister, R. et al. Human DNA methylomes at base resolution show widespread epigenomic differences.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com