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Despite advances in high throughput proteomic characterization of aberrant protein expression and disease-specific differentiation from normal colonic tissue, very few biomarkers have been found to be clinically useful and have attained widespread clinical application [ 23, 24].
The simplicity and accessibility of this method should allow its widespread clinical application.
Widespread clinical application is hindered by toxicities related to recipient pre-conditioning.
Although a number of approaches are under investigation, none has been sufficiently successful to warrant widespread clinical application.
Although successful in selective treatments, tissue engineering needs to overcome major challenges to allow widespread clinical application with predictable outcomes.
Bone lengthening through callus distraction (callotasis) has widespread clinical application in the management of many orthopedic conditions [1, 2, 3, 4, 5, 6, 7].
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This approach may be able to scale current engineered tissues to clinically relevant dimensions, opening the way to their widespread clinical applications.
However, in vivo delivery issues still represent a significant obstacle for widespread clinical applications.
However, advances in cellular targeting and intracellular delivery will probably lead to more widespread clinical applications.
Widespread clinical applications of peptide drugs have been hindered by their low stability and selectivity.
As the free alcohol, betamethasone finds widespread clinical applications related to its anti-inflammatory and immunosuppressant activity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com