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The first was troubled by sound problems there was widespread amplification, which, as usual, worked poorly at Carnegie and also by a basic sense that this unabashedly over-the-top piece didn't belong in the grand old hall.
The first was troubled by sound problems — there was widespread amplification, which, as usual, worked poorly at Carnegie — and also by a basic sense that this unabashedly over-the-top piece didn't belong in the grand old hall.
In addition to confirming a central role for OCT4 and SOX2 in reprogramming by defined factors, our model also suggests that non-specific widespread amplification of transcriptional noise may aid reprogramming of somatic cells to a pluripotent state.
(2) In the absence of environmental stimulus to differentiate, non-specific widespread amplification of transcriptional noise in this case, amplification of noise in the expression of all 6 genes is also sufficient to trigger stochastic transitions to the pluripotent state.
RVFV reemergence, caused by floodwater mosquitoes, is followed by widespread amplification in high-risk animal populations and progressively greater prevalence among animals.
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To enable a simple, economical, and high throughput assay configuration, we selected a single locus for PCR in the TBP gene, chosen because it is devoid of widespread gene amplification or deletion events in cancer.
However, they also suggest that it is not necessary to target OCT4 and SOX2 specifically, but rather reprogramming may also be achieved by widespread non-specific amplification of transcriptional noise.
Comparative genome hybridization (CGH) analysis of breast cancers and other carcinomas from late-generation mTERC-/ p53+/- mice revealed widespread regions of amplification or deletion, significantly altering gene copy number [ 15].
Our data during 2003 clearly showed that WNV introduction, amplification, and widespread dispersal occurred with few human or horse cases, indicating that such cases are insensitive indicators of WNV presence and enzootic activity levels.
Both tumor types featured widespread genomic instability, MYC amplification, and loss of BRCA1, TP53, and RB1, leading to the authors' conclusion that patients with basal-like tumors may benefit from poly ADP-ribose polymerase (PARP) inhibitors or platinum-based therapies.
More explicitly, the widespread scatter of "real frequency" amplification factors, due to the combined variability of fundamental frequencies and amplification values, is redistributed in the normalized frequency domain.
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