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NPY signals via a family of high affinity receptors that mediate the widespread actions of NPY in all hypothalamic nuclei.
This may be an explanation for the widespread actions of estrogens on the brain.
The lack of known widespread actions of unliganded TR in mammals may be because low levels of TH are present in the fetus such that effects of unliganded TRα may appear only in hypothyroid conditions as in the cochlea.
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In contrast to more widespread action of E2, GLP-1 action is restricted to tissues presenting the GLP-1 receptor at its cell surfaces.
One can speculate that the widespread action of gelatinases on the synaptic ECM leads to the weakening of the physical constraints imposed on both pre- and postsynaptic domains, thus enabling their training-induced expansion.
Emissions from marine traffic and dispersed in coastal areas are growing in recent years in part because of widespread actions worldwide aimed to reduce emissions deriving from road transport sector during the last years [3].
Despite the widespread action, which involved seizures of servers that co-ordinated the running of Citadel, the identity of the botnet's main controller is unknown.
"We are not aware of any widespread action by counties to substantially reduce retiree health insurance," he said.
Politicians insist that urgent and widespread action can yet prevent the worst of global warming but the cracks in that argument have been showing for some time.
The restoration of the monarchy in 1660 led to special legislation against the Quakers and a widespread action against them.
Given the widespread observed neuroprotective actions of GDNF against NMDA-induced neurodegeneration even in the subregions that poorly respond to GDNF stimulation, (cfr Fig. 3), we examined by immunoblotting the activation pattern of the Ret receptor following NMDA insult in presence or in absence of GDNF (Fig. 6A-B).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com