Sentence examples for widespread accumulation from inspiring English sources

Photosynthesis provided a source of free oxygen, but the loss of reducing agents such as hydrogen is believed to have been a necessary precondition for the widespread accumulation of oxygen in the atmosphere.

For the present study we chose to focus on DLB because of its frequency and widespread accumulation of a-syn in neocortical and limbic structures [46], [47], [48].

Instead, these trends could be symptomatic of some long-term and widespread accumulation of extinction risk across the world's seas and oceans.

"As we see throughout the entire world, the illicit trade in small arms and light weapons and their widespread accumulation and misuse have a wide range of negative humanitarian and socio-economic consequences," said Ms. Salah.

Here we present yet another pathological feature in the diseased muscle fibers: widespread accumulation of autofluorescent lipofuscin inclusions, which have previously been recognized as a sign of ageing [ 23, 24].

Pre-postmortem stage affected retina have only been studied in CLN3-deficient mouse models, where retinal degeneration is first indicated by widespread accumulation of this characteristic autofluorescent storage material in the photoreceptor and ganglion cell layers (16, 19, 20).

A spokeswoman for RCT council said: "This snow is expected to be particularly severe between 3am and 9am and is likely to lead to widespread accumulations of four inches with six to eight inches over higher ground".

Immunohistochemical studies showed widespread accumulations of PrP-immunopositive deposits throughout the brain of each monkey.

They closely and widely contact the source rocks, comprising a very favorable source reservoir assemblage horizontally, which has laid the foundation for widespread gas accumulation in the reservoirs and then the discovery of large scale reserves (Figs. 2, 3).

Niemann-Pick type C (NPC) disease is a fatal neurodegenerative disorder caused most commonly by a defect in the NPC1 protein and characterized by widespread intracellular accumulation of unesterified cholesterol and glycosphingolipids (GSLs).

Disease was confirmed by identification of widespread PrPd accumulation in the CNS by immunohistochemistry (Fig 1a) and detection of proteinase K resistant PrPSc by Western blotting.