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Over a 2-h period, relatively early in embryogenesis in absolute terms, the male embryos go from appearing phenotypically normal to showing widespread abnormality.
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For diffuse or widespread abnormalities, the boundary line included all of the abnormal area and asymmetric densities were annotated in a similar fashion.
Autism is one of the five pervasive developmental disorders (PDD), which are characterized by widespread abnormalities of social interactions and communication, and severely restricted interests and highly repetitive behavior.
Unlike the widespread abnormalities of the Minute fly mutants, mutations in RP genes in mammals are associated with regional abnormalities.
Trials with widespread abnormalities were reacquired after adjusting arena and detection settings, and standard 2D images of the swim track were generated for all animals tested.
In contrast, immunofluorescence assays for expression of five respiratory chain complexes showed widespread abnormalities.
In nHCM patients, there are widespread abnormalities of both systolic and diastolic function.
In addition, more widespread abnormalities were observed using diffusion imaging in line with Braak's staging hypothesis.
Neonatal parathion exposure evoked widespread abnormalities in ACh synaptic markers, encompassing effects in brain regions possessing ACh projections and ACh cell bodies.
Conversely, myofibers from DNM2-S619L zebrafishadad widespread abnormalities in RyR1 and DHPR staining, including aggregation of staining and interruption of the normal confluent linear pattern (Fig. 1F,G).
Our main hypothesis was that with greater statistical power, and by examining all implicated tracts, we would reconcile the apparently inconsistent findings in the literature by revealing widespread abnormalities in schizophrenic white matter.
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