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To attempt to separate putative pyramidal neurons (wider spike) from putative interneurons (more narrow spike) (González-Burgos et al. 2005; Mitchell et al. 2007), action potential width was quantified as the time interval between the two extremes of the extracellular voltage (Supplementary Fig. S1A).
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The positive correlation indicates that cells with wider spikes tend to fire earlier in the gamma cycle than cells with narrower spikes, i.e. firing of putative pyramidal neurons precedes that of putative interneurons.
"LIPA does experience a system-wide spike in electric use during the holiday season, partly because of holiday lights but more probably because of increased cooking and lighting in general," said Michael C. Lowndes, the manager of media relations for the Long Island Power Authority.
At gCaT = 0.19 (as in B), the vertical line intersects three points indicating three voltage maxima-two spikes and a wide spike prior to burst termination.
At gCaT = 0.35 (as in C) the line intersects four voltage maxima-three spikes and a wide spike prior to termination, while at gCaT = 0.5, there is intersection with five points indicating five voltage maxima-four spikes and a wide spike prior to termination.
We examined the contribution of inward currents during a burst, specifically contributions to the model-generated action potential spikes, afterdepolarizing potential (ADP), and the wide spike prior to burst termination.
We used the model simulations to investigate the inward currents during phases of the burst, including rapid depolarization, afterdepolarizing potential (ADP), and the wide spike prior to burst termination.
For this analysis, the waveforms were compared to the widest spike in the dataset (which was designated the value of 1).
MEA data were quantified using the array-wide spike detection rate (ASDR), defined as the number of spikes detected in all contacts of the MEA during each second of recording.
The question we ask is: Do beyond-pairwise correlations play an important role in determining the population-wide spike-count distribution?
These analog waveforms (templates) consisted of 5 ms wide spike-shaped voltage transients that departed from and returned to a rest state of −60 mV.
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