Sentence examples for wider selectivity from inspiring English sources

A key challenge in the design of multiple ligands is attaining a balanced activity at each target of interest while simultaneously achieving a wider selectivity and a suitable pharmacokinetic profile.

Compared to optimizing the balance of affinities and the wider selectivity, an even greater challenge for medicinal chemists when confronted with the challenge of designing multiple ligands is to obtain physicochemical and PK properties consistent with developing an oral drug.

This binding was entirely driven by enthalpic interactions (Δ H=−11 kcal mol−1), with a net loss in entropy upon binding (TΔ S=−2.0 kcal mol−1), which is consistent with a number of specific interactions and may offer an advantage for wider selectivity.

DDR1-IN-1 is a selective DDR1 kinase inhibitor that through kinome-wide selectivity profiling and biochemical assay confirmation was not observed to target other protein kinases when used at concentrations of less than 10 μM.

The results provide a unique, universal and versatile tool with wide selectivity in both ink and substrate.

We showed continuous pulling of flexible NFs, accompanied by in situ mechanical interpretation with a wide selectivity in nanomaterials (inks) and substrates for versatile and direct fabrication.

However, at a low concentration under ~10−4 M, the nanoscale NaCl crystal pillars were easily produced by the NF fabrication (Additional file 1: Figure S7). Figure 3 Wide selectivity in ink and substrate for diverse nanofiber fabrication.

Several of these nine compounds exhibit a wide selectivity window with difference in −logGI50 between tumorigenic and non-tumorigenic cell lines of two or more.

Large neutral amino acid transporter (L system, LAT1) is reported to have wide selectivity in transporting molecules.

Although built on a promiscuous scaffold, we anticipated that the larger substituents of our improved inhibitor (the cyclobutyl and benzimidazole moieties) would improve its kinome wide selectivity.

We assembled a library of approximately 3000 diverse inhibitors and screened a subset of the library for kinome-wide selectivity profiling using binding (KinomeScan) [ 25], enzymatic (SelectScreen, Invitrogen Carlsbad, CA) and chemical proteomic approaches (Kinativ) [ 26].