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A larger or wider sample size would be needed to confirm this.
The high sensitivity and reproducibility of this new diagnostic algorithm strongly support a further validation on a wider sample size.
However, the high sensitivity and reproducibility of this new diagnostic algorithm strongly support a further validation effort on a wider sample size, to investigate whether this potential tool could become a part of the routine diagnostic procedure.
Moreover, further replication studies using a wider sample size and different population would be essential for further evaluation of the relationship between the CXCL12 genetic variations and the risk of asthma.
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There are some strong points of our study including face-to-face assessment of headaches by a specifically trained physician group with electronic database system, a large nation-wide sample size and a random population, strict application of the ICHD-II diagnostic criteria of the IHS excluding the subjectivity of the physician's diagnosis.
Although the ranges of values for the covariates tested were wide, the sample size was very small.
But the confidence intervals were not that wide, therefore sample size is adequate for the interpretation of results.
This is dependent upon the number of simulations (especially construction-wide assessment), sample size, number of SNPs considered and threshold values.
Data provided by group 1 provided preliminary data (wide variation/small sample size) that compared subjects with severe shoulder impingement to age-matched controls with no shoulder pathologies.
Nevertheless, because non-parametric tests trade-off power for increased robustness and wider applicability, the sample size for most RNAi screening studies will be too small to enable conclusions from non-parametric tests with the same degree of confidence as from parametric tests.
In the case of the more reliable subsets of phosphoserines observed in several experiments, the subtitution rate to aspartate and glutamate is even higher, and also lies outside the interval of bootstraps that in this case is wider, as the sample size is smaller.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com