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Also, results in this range of cutoff values were relatively unaffected by fragment length differences, permitting the inclusion of a wider range of sequences in the dataset.
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The species from the NW, in contrast, form a single peak which is skewed and covers a wider range of sequence identities (44 to 73%).
In contrast to this, UCLUST is optimized for detecting a wider range of sequence similarities based on common word matches in its initial search step.
Our present work differs from earlier similar surveys not only by investigating a wider range of sequence patterns in a large number of genomes but also by using a more realistic null model to assess significant anomalies.
Our present work differs from earlier similar surveys not only by investigating a wider range of sequence patterns in a large number of genomes but also by using a more realistic null model to assess significant deviations.
The reason that we used more stringent parameters for the analysis of 16S sequences is that the SILVA database covers a wider range of sequence diversity [ 18], is smaller and better curated than NCBI-NR, and thus it is easier to obtain high-scored alignments.
Combinatorial protein libraries permit the examination of a wide range of sequences.
We have previously shown that for a wide range of sequences the degree of repetition is strongly dependent on the probe length [18].
This method yielded a wide range of sequences per individual, with an average of 7,596,336 post quality filtering (range: 319,559 – 24,263,032; see Additional File 1).
Given the wide range of sequences studied, it is not particularly surprising to observe all these variations associated with the detected pseudoknots.
Instead, we find that those in Class I (the entire lower half in Figure 4) bind a wide range of sequences, and that the RH cannot be the only determinant of sequence specificity.
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