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The mammary tumors that do develop tend to be more poorly differentiated, aneuploid tumors with a wider range of phenotypes.
In contrast, when Ush is expressed only in the AS of ush mutants, we observe a wider range of phenotypes in cuticles, including complete rescue of GBR and DC, and a 30% increase in embryonic viability (Table 3).
Our expectation is that if the frequently seen genes are arising as candidates in more studies, and are less likely to be truly pathogenic, then they could be associated to a wider range of phenotypes in the literature (we recognize the association could also be due to pleiotropy [ 45], see Limitations).
Similarly, because the PC12 line has two defined differentiation end points (acetylcholine and dopamine), it can be readily used to evaluate the potential of test agents to interfere with the appearance of neurotransmitter phenotypes, providing a proof of principle for neurotransmitter switching; this leads the way to examining a wider range of phenotypes in vivo.
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In model organisms, the interest is to map a wide range of phenotypes within a series of highly controlled lines that still display sufficient phenotypic diversity.
In addition, to ensure a comprehensive evaluation, the training and the external validation need to be performed on multiple pairs of training and test datasets that encompass a wide range of phenotypes with varying extent of relative subtlety in the biological differences between phenotypic classes.
In QTL studies over the past 20 years, major QTLs controlling a wide range of phenotypes have been identified.
These patients may represent the severe end of a wide range of phenotypes and thus individualization of treatment for each patient may be justified.
Skin pathology comprises a large number of rare inherited diseases, known as genodermatoses, with a wide range of phenotypes and severities.
The importance of ClC channels has in part been realized through studies of inherited human diseases and genetically engineered mice that display a wide range of phenotypes from kidney stones to petrified bones.
Like W5, a wide range of phenotypes were observed.
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