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The slight heterogeneity in planning may actually increase the ability to identify important DVH relationships by providing a wider range of dose to the normal tissues.
In contrast, the +IM model predicted a much stronger synergy across a wider range of dose combinations, probably due to the presence of additional feedback loops between the target steps of the two drugs via the immune system.
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In the future, this study could be extended to identification of the skin's regenerative processes after irradiation at later times and after a wider range of doses of low-LET and high-LET radiation including heavy-ions and protons.
First, we collected detailed, updated information on aspirin use at a wider range of doses and over longer follow-up than would be feasible to examine in most other studies.
Taken together, this suggests that a wider range of doses is needed to evaluate the efficacy and safety of MPH in substance-dependent patients with ADHD.
The safety profile of etanercept might be apparently superior because the other drugs were tested over a wider range of doses, including higher than recommended ones.
Subsequently, model parameters corresponding to a wider range of doses (i.e. including both low-dose and high-dose behavior) were estimated using dose-response data (for doses ranging from 0.1 - 10 μM) reported by Drobna et al. [ 53].
Since 1 g/day is the currently recommended daily dose of EPA/DHA for adults with coronary heart disease (30), further research is also needed to evaluate the effects of n-3 PUFA across a wider range of doses.
Recent studies of selective SNRIs have assessed a wider range of doses, which have been well tolerated by most patients and effective in reducing many of the symptoms and impact of fibromyalgia.
A more complete analysis would have required a wider range of doses and using one mouse brain hemisphere for histology and the other for quantitative biochemical analysis of Aβ species.
For diazinon and parathion, prior information on systemic toxicity using this vehicle and route was not available, so we evaluated a wider range of doses: 0.05 5 mg/kg for diazinon and 0.01 5 mg/kg for parathion.
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