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The ability to utilize both pH and temperature as selectivity variables allows the chromatographer to exploit a much wider method development design space including previously prohibited alkaline conditions.
Hence, family planning programmes need to prioritise provision of wider method choices, including those with better effectiveness and convenience.
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The mass release of sterile insects (the Sterile Insect Technique, SIT) is a highly effective area-wide method of pest control with a low environmental impact.
Thus, we only try to compare drugCIPHER with a currently available non-genome-wide method, the BLM [11], which is also the most precise model for target prediction.
Therefore, a genome-wide method to directly quantify differences in RE cleavage would be highly desirable in these assays.
The development of microarray analyses represents a genome-wide method for measuring differences across strains, focusing on expression differences.
In this study, we developed a unique genome-wide method to discover DNA motifs associated with chromatin accessibility.
It is also important to note that, since target selection is part of the procedure, these methods do not represent a genome-wide method.
The development of microarray analyses represents an additional genome-wide method for measuring differences across strains, focusing on expression differences rather than on sequence differences in the genome.
In summary, in this work we present a genome-wide method for the identification of sequences that replicate early in the S phase.
We developed a unique genome-wide method to discover DNA motifs associated with chromatin accessibility using formaldehyde-assisted isolation of regulatory elements with high-throughput sequencing (FAIRE-seq).
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