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If there is a relationship between gata3 and PKBβ/Akt2 in vivo then, despite the wider expression pattern of the latter, the two proteins should be co-expressed in sensory epithelia and spiral ganglion neurons during periods of high gata3 expression.
Similarly, redundancy is likely to restrict the phenotype to the eye, despite the wider expression pattern of the Sall2 gene; for example, homozygous deletion of Sall1 results in severe kidney dysgenesis, whereas Sall2-deficient mice have normal kidneys despite both genes being expressed during kidney development (33, 52).
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(A) Genome-wide expression pattern of primary normal human stromal cells.
The genome-wide expression pattern of blood leukocytes was sequentially compared to healthy volunteers and after stratification based on Simplified Acute Physiology Score II (SAPSII) score to identify potential mechanisms of dysregulation.
During the last decade, transcriptome analysis using microarray technology has provided an understanding of the genome-wide expression pattern of a species in a trait-specific manner.
Despite the wide expression pattern of Erg isoforms 1-4 in the developing cartilage and joints, the homozygous null animals were viable, fertile and did not display any overt phenotype.
This study provides an important overview of the genome-wide expression patterns of blood leukocytes over three time points (within 30 min after diagnosis and 24 and 48 h afterwards).
As trauma and septic shock share similarities in pathophysiology and as the understanding of the global host response in sepsis would have a major impact on the successful use of targeted therapies [3], the main objective of the study was to analyze the genome-wide expression patterns of blood leukocytes sequentially during the first 48 h after septic shock.
At P3 and P7, genome-wide expression patterns of wild type and α9−/− samples clustered together.
Using cDNA microarrays, we analyzed the genome-wide expression patterns of human fibroblasts homozygous for the I1061T NPC1 mutation that is characterized by a severe defect in the intracellular processing of low density lipoprotein-derived cholesterol.
Using these differing filtering methods for contigs with putative physical locations, we compared chromosome-wide expression patterns of the Z and autosomes, between males and females.
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