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Second, contrary to solution formations, the concentration of nanosuspension is not limited by solubility in the vehicle, thus, a wider dose range can be achieved.
In tests with various human cancer xenograft models, capecitabine was more efficacious at wider dose ranges than either 5-FU or 5′-DFUR and was significantly less toxic to the intestinal tract than the others in monkeys.
These results support an earlier meta-analysis by Livesey & Taylor, which did not show a dose threshold for HbA1c reductions across a wider dose range of fructose.
Updates of the revised cohort resulted in the wider dose range compared with the original Canadian study, but mean doses were similar (21.64 vs 19.13 mSv).
In human colon cancer xenograft models, capecitabine was more effective at wider dose ranges than either 5-FU or 5'DFUR and showed a minor gastrointestinal toxicity [ 15].
Individualised dosing taking renal function, body height and an acceptable toxicity into account therefore results in a wider dose range than the empirical dosing.
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This is particularly exciting as it may allow for wider dosing intervals.
Whereas inclusion of this very low dose would have allowed an examination of trends across a much wider dosing range, this dose was shown to be non-therapeutic in the study [ 2], is unlikely to be utilized in clinical practice, and could lead to a distortion of the trends in the true dosing range of olanzapine LAI.
HN2 challenge was administered via the apical (air) interface over a wide dose range (20 400 μM) to differentiated HBE1 cells.
The yield of γ-H2AX foci has been shown to be linearly related to dose over a very wide dose range.
In general, the MMAD of our optimized delivery setting was found to be about 3.7 ± 0.3 μm throughout a wide dose range (Table 1).
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