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Potassium binding has recently been shown to regulate the activity of HDAC8.[ 19] Crystal structures of HDAC8[ 20] show that the Cζ of R223 is ca. 12 Å from one of the two potassium binding sites, which allows us to investigate the wider consequences on the side-chain packing of K+ binding.
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Arguments, at best, make certain value judgments plausible as hypotheses — and even then, only if grounded in experience and reflection on the wider consequences of acting on them.
Nevertheless, what makes desire a sound guide to the good is the fact that it incorporates foresight and reflection on the wider consequences of acting on it, not just that it incorporates a liking of its object (E 195 6).
But the Federal District Court overseeing this case through a decade of tiring litigation seems more focused on cramped legal interpretations and the morality of debt than on the wider consequences of its rulings.
"The Federal District Court overseeing this case through a decade of tiring litigation seems more focused on cramped legal interpretations and the morality of debt than on the wider consequences of its rulings".
36 We can only speculate about the wider consequences of the potential negative impact of sickness absence on social support at work, as suggested by our results.
Jim Killock, executive director of Open Rights, said: "We need to think about the wider consequences of allowing companies to make decisions that affect us financially or otherwise, based on what we have said on social media.
What are the wider consequences of trachoma?
Much of the direct effect of near miss with perinatal death on increased risk of psychological distress was shown to be mediated through wider consequences of traumatic childbirth.
In silver birch, elevated atmospheric humidity had the widest consequences on stomatal regulation, as the effects extended beyond that of soil water availability.
The evolution of novel miRNAs could have genome-wide consequences on gene regulation owing to the small motifs of sequence complementarity required for binding to potential targets (Bartel 2009; Zheng et al. 2011).
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