Sentence examples for wider burden from inspiring English sources

14 Even during periods between pandemics, children experience considerable morbidity and mortality from influenza infection, and their role in virus transmission results in a much wider burden.

These two pathogens are responsible for the more severe forms and sequelae of OM, so effective vaccination against them could materially reduce OM's clinical impact and wider burden [ 68, 75].

Given the population-wide burden of CMRD, novel ways of assessing risk and providing feedback to support behavior change are needed.

This genome-wide burden suggests an extensive polygenic contribution to SUDEP causation.

The burden test used in our genome-wide burden analysis is sensitive to linkage disequilibrium (increased type I error rate).

The variant selection procedure for the genome-wide burden analysis is detailed in the Supplementary Method 8.1.

Variant and individual-level QC was performed as for the genome-wide burden analysis (Supplementary Method 6).

We tested the genome-wide burden of rare (or novel) deleterious variants in the SUDEP cohort against both control cohorts separately.

Although there was also a significant difference in the number of variants between the two control cohorts (P = 6.1 × 10− 3), the genome-wide burden score did not differ.

Understanding these processes can offer new targets for therapeutic intervention and are of increasing necessity, regarding the growing world-wide burden of diabetes.

The genome-wide burden of rare CNVs was assessed according to either the number of rare CNVs per sample or the average rare CNV size per sample.