Widening the intervals reduces overall significance.
Therefore, a precise knowledge of the doubling time would allow to safely widen the interval between CMV PCR testing, without an increase in CMV disease episodes.
On the other hand, the single uncertainty-based models are presented to achieve better performances when the temperature is mild since it is enough only taking temperature into account, while considering dual uncertainty may act as a conservative estimation by widening the forecasting interval.
In addition, evidence for widening the confidence interval of the ovary size QTL exists when the evidence from ABC3 and ABC5 is combined (see Figure eight in [ 22]).
The overlap between aff2 and the ovary size QTL on chromosome 11 was only detected with after widening the confidence interval for aff2.
This reduced the significant associations to null, altering the effect estimates and widening the confidence intervals.
If the model is correctly specified and the effects are constant throughout the population, this does not present a problem, other than the lowered sample size widening the confidence intervals.
It is, therefore, a combined approach which aims to maximise accuracy where missing values are predicted and to adjust the precision of any estimates derived from these predictions (e.g. by widening the confidence intervals on estimates of cancer incidence).
This approach was felt to be more conservative than alternate strategies, such as using generalized estimating equations that account for the within-person variance by widening the confidence intervals of the PPV, NPV, Se and Sp, but leave the point estimates unchanged.
Including unpublished data in the internal report and individual participant data analyses increases relative risks at six months because of one unpublished trial (rhBMP-2/BCP Canada pivotal), which indicated a strongly beneficial result at this time point, with the increase in heterogeneity widening the confidence intervals.
