Duplex RNA segments have A-form C3′ endo sugar puckers but widened major groove widths, giving the RNA an overall architecture that mimics B-form promoter DNA.
On Long Island, planners are moving forward with a controversial scheme that will widen major roadways by 2020 by adding lanes serving only multipassenger vehicles.
Thanks in no small part to the misguided obstinacy of successive generations of visionless political leaders, Los Angeles is now playing catch up for the decades of missed opportunities to build rail instead of new lanes on the freeway and to ceaselessly take private property to widen major, and minor, thoroughfares through dozens of once proud neighborhoods.
For instance, a common mechanism for stimulating HIV-1 integration is DNA bending, which creates a widened major groove at the outer curved face that is favorable for integration [49], [56], [57], [58], [59].
The results show for dsRNA a perfect A-form, except in one region of widened major groove (experimentally confirmed for dsRBDs).
The bulge structures may distort the A-form helix by widening the major groove and increasing the accessibility of its functional groups.
The substituted south constrained nucleotides in the dodecamer widened the major groove and narrowed and deepened the minor groove thus inducing local conformational changes that resemble a B-form DNA helix.
Kyōto was the first city in Japan to have electric streetcars (starting in 1895), which eventually made it necessary to widen the major thoroughfares to allow for citywide service.
In 20 years of near-constant reform efforts, Chicago's elementary school students have made few gains, high school students have advanced, and the achievement gap between poor and rich areas has widened, a major University of Chicago study found, contradicting impressions created by years of Chicago Public Schools testing data.
