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Orphan genes, candidate genes with wide-ranging functions (EIF4A2) or without sufficient functional characterization (NAP1L5, GNAS), can only be associated tentatively with major deregulated pathways identified in this study, and were omitted from Figure 7.
These natural properties have been utilized to assemble varieties of RNA nanoparticles with diverse biological properties and wide-ranging functions.
Interleukin-6 (IL-6) is a pleiotropic cytokine produced by multiple cell types and with wide-ranging functions and actions.
They are thought to be primarily involved in determining calcium and sodium entry and have wide-ranging functions that include regulation of cell proliferation, motility and contraction.
The authors also discuss emerging evidence for its wide-ranging functions in development, pluripotency, cellular differentiation and cell cycle regulation, which underscore the complexity of its functions.
The genes and proteins of the GH18 family have primarily been studied in humans and mice, and these studies have elucidated their wide-ranging functions in immunity and tissue homeostasis.
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In particular, the research found that pharmacists working in these positions performed wide-ranging management functions as part of the district or sub-district management team, albeit with a particular responsibility for pharmaceutical services.
The ability of Hfq to affect such wide-ranging cellular functions is likely due to its role as an RNA chaperone for sRNAs.
Recently, miRNAs have been found to have wide-ranging regulatory functions in cell proliferation, differentiation and many other processes [ 27], but only a few studies have focused on the interaction with WNT signaling during adipogenesis.
DOI: http://dx.doi.org/10.7554/eLife.04353.003 The wide-ranging physiological functions of ankyrins are the result of ankyrin's remarkable capacity for binding to and anchoring numerous membrane targets, via their N-terminal 24 ANK repeats, to specific membrane micro-domains in coordination with spectrin-based cytoskeletal structures (Bennett and Chen, 2001).
This review article provides an overview of the genesis of elastin and its wide-ranging structure and function.
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