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Cyclic nucleotide phosphodiesterases (PDEs) are a diverse enzyme group with multiple regulatory properties and wide tissue distribution.
Moreover, targeted mutations in MLN64 (Stanotheranother START member with wide tissue distribution, impair steroidogenesis while causing minor alteration in cholesterol metabolism [93].
The method of grid crossings proposed here can instead be applied to big image data sets, allowing to obtain measures over wide tissue portions in a limited time.
We validated several parameters, including area, perimeter, Feret's diameter (caliper), circularity, aspect ratio, and solidity, providing quantitative information on M/M morphology over wide tissue portions.
CYP7B1 is known to have wide tissue distribution, but has not been previously identified in the human ovarian follicle [9].
The amino acid, osteocalcin, and divalent calcium ligand specificity of this receptor and its wide tissue distribution implicate GPRC6A multiple processes.
It has a wide tissue distribution and is, besides WAT and brown adipose tissue (BAT), expressed also in steroidogenic tissues, skeletal muscle, macrophages and pancreatic β-cells.
They share significant sequence similarity and wide tissue distribution, and are only distantly related to the Group 2 Trp channels (TrpML and TrpP subfamilies).
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Therefore, while the TCRα LCR is able to support high-level transcription of a 3'-flanking reporter gene that is protected from integration site-dependent position effects, it alone cannot confer upon the reporter the wide tissue-distribution of high-level activity characteristic of Dad1 gene expression.
We found that the oldest and thickest layer (dN/ dS) consists of system-wide tissue and organ adaptations.
Since L1 and Alu elements make up almost 30% of the genome, REs may bias genome-wide tissue comparisons of DNA methylation based on total 5-mC content.
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