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Indeed, perhaps the disadvantage of spanning such a wide timescale is that Sinclair's work is constantly changing and adapting to new conditions and ideas; her early New Woman novels bear little resemblance to her later modernist works, though there is little difference in quality.
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The nature and extent of genetic polymorphisms accumulated in the genome of bacterial pathogens across wide timescales and during the colonization of different host niches are not known.
Another difficulty in estimating the relative timing of the two types of duplication events is that, although WGD paralogs will arise at the same time, the LGD events will be happening over a wider timescale.
The wide range of timescales and complex relationships among the motions at different timescales make it difficult to capture the biologically significant, long-timescale dynamics of protein motion in a compact model.
Concentrations of greenhouse gases have varied substantially during Earth's history, and these variations have driven substantial climate changes at a wide range of timescales.
One reason might be that a collisional stellar system spans a wide range in timescales.
In fact, this requires a technique that can interrogate molecular interactions over a wide range of timescales.
In order to efficiently handle the wide range of timescales in a non-uniform cosmological simulation, ChaNGa allows each particle to have its own time step.
Addressing the wide span of timescales, where various important phenomena takes place in a polymer system, is inconceivable through a typical molecular dynamics simulation.
The microtubule-based metaphase spindle is subjected to forces that act in diverse orientations and over a wide range of timescales.
These technically challenging goals may be achieved by combining time-resolved spectroscopic and structural kinetic tools, thus providing broad insights into specific molecular events over a wide range of timescales.
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